Antibody Panel to proteins of the superoxide dismutase enzyme family (SOD1, SOD2, SOD3, SOD4)

*   disables radicals

Superoxide dismutase (SOD) is an antioxidant enzyme and as such part of the defense system against reactive oxygen species (ROS). SOD catalyses the dismutation reaction of the superoxide radical anion (O2-) to hydrogen peroxide (H2O2) through glutathione reductase and catalase.
Several classes of SOD have been identified. These include the intracellular copper/zinc SOD (Cu/Zn-SOD, SOD-1), the mitochondrial manganese SOD (Mn-SOD, SOD2) and the extracellular copper/zinc SOD (ECSOD, SOD3).
SOD-1 is found in all eukaryotic species as homodimeric 32 kD enzyme, which does contain one Cu- and one Zn-ion each.
The Mn-containing, tetrameric enzyme SOD2 is localized at the mitochondrial matrix, in close proximity to the primary endogen source for superoxide, the respiratory chain. For this reason it is excellent as mitochondrial marker.
SOD3 is a heparin-binding multimer of dimers, which is expressed primarily in human lung, vessel walls and airways.
SOD4 is a Cu-Chaperon for SOD (CCS), which specifically delivers Cu to SOD4. CCS presumably activates the Cu/Zn SOD by direct insertion of the Cu-cofactor.

Fig. 1: Western blot analysis of tissue lysates with SOD-2 antibody LF-MA0030
Lane 1: HeLa cell lysate
Lane 2: Mouse brain
Lane 3: Ratte brain

Detection and Analysis of SOD

Acris Antibodies offers a vast selection of antibodies, proteins and ELISA kits (see table below), which can be used to analyse the four isoforms of SOD in Western blots and other methods. Especially LabFrontier’s ELISA kits may provide valuable data, f.e. to investigate the role of SOD1 in tissues that have been stressed by heat, hypoxia or radiation. SOD2 seems to play a role in cancer, aging and transplant rejection.

All SOD products: SOD-1 antibody, SOD-2 antibody, SOD-3 antibody, SOD-4 antibody, SOD-1 protein, SOD-2 protein, SOD-3 protein, SOD-4 protein, SOD-1 ELISA Kit, SOD-2 ELISA Kit.

 

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