Antibody Panel to ink4 Protein Family

Introduction

Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. The D type cyclins complex with CDK4 and CDK6 to govern progression through the G1 phase of the cell cycle and later are involved with inactivating phosphorylation of the RB protein, which results in release of RB-associated transcription factors that are needed for entry into S phase. The activity of the cyclin D-dependent kinases is, in part, controlled by inhibitors such as the INK4 family.

INK4 family includes INK4a (CDKN2A); 4b (CDKN2B); 4c (CDKN2C), and 4d (CDKN2D).

Reportedly, p15INK4b expression is induced approximately 30-fold in human keratinocytes by treatment with TGF-beta, suggesting that p15INK4b may act as an effector of TGF-Beta-mediated cell cycle arrest. p18INK4c and p19INK4d are expressed during G1 -to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase.

Antibody Tools for the Detection of ink4

Acris Antibodies offers a panel of antibodies to ink4 proteins which are suitable for Western blotting, immunohistochemistry or other detection methods.

Fig.1: Formalin-fixed, paraffin-embedded human colon carcinoma stained with p15INK4b antibody (DM379) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.

Fig.2: Formalin-fixed, paraffin-embedded human tonsil stained with p18INK4c (AM00301PU-N) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of cells.

Available Antibody Panel to ink4 Protein Family

Anti- p15INK4b (CDKN2B, MTS2), p18INK4C (CDKN2C, CDKN6), p19INK4d (CDKN2D) antibody

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