Antibodies to Protein Phosphatase 2

Introduction: Protein phosphorylation is dependent on the opposing actions of protein kinases and protein phosphatases. Four major protein phosphatases have been identified in the cytosol of eukaryotic cells which are responsible for the dephosphorylation of serine and threonine residues in proteins. Although all 4 protein phosphatases, PP1, PP2A, PP2B, and PP2C, have overlapping substrate specificities in vitro, they can be distinguished by the use of inhibitor proteins and by their dependence on metal ions.

Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit (PP2A, PP2CB, PPP2CB) might modulate substrate selectivity and catalytic activity.

Protein phosphatase 2C(PP2C alpha) is a Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNK MAPK pathways and regulates cellular stress response in eukaryotes.

Antibody Tools for the Detection of PP2A and PP2C

Acris Antibodies offers an antibody panel to Protein Phosphatase 2 family, suitable for immunological detection methods like Western blotting or immunoprecipitation.

Antibody Panel to Protein Phosphatase 2

Protein Phosphatase 2 A (PP2A, PPP2CB) antibody, Protein Phosphatase 2C (PP2C), PP2C alpha, PP2C alpha / beta and PP2C delta (PPM1D) antibody