Antibodies to Fyn Kinase

Introduction

Fyn (p59fyn) is a membrane-associated non-receptor protein tyrosine kinase of approximately 59kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B-cell and T-cell activation as well as keratinocyte differentiation. In T-cells, Fyn associates with the Tcell antigen receptor and Thy-1.

Antibody Panel to Fyn Kinase

Acris Antibodies offers a wide range of antibodies to Fyn kinase, which are suitable for Immuno¬histochemistry, Western Blot and / or other immunological detection methods.

Antibody Panel to Fyn

Fyn Kinase, FGR, YES, MGC45350, p59-Fyn, Syn, SLK–antibody.

Literature

Chin J, Palop JJ, Puolivali J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 2005 Oct 19; 25(42): 9694-703.

Li H, Lawrence DS. Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy. Chem Biol. 2005 Aug; 12(8): 905-12.