Antibodies to Adenosine Receptors

Introduction

The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis.

Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon, biochemical and pharmacological criteria, ARs have been classified into A1, A2a, A2b, and A3. The high affinity receptor A1 inhibits adenyl cyclase, whereas low affinity receptor A2a stimulates the cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in coronary artery. Various, ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and predicted to contain 7 transmembrane domains. The N-termini are predicted to be extracellular and the C-termini cytoplasmic. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromosome 1).

Antibody Tools for the Detection of Adenosine Receptor Subtypes

Acris Antibodies offers a panel of antibodies to ARs. These antibodies are suitable for immunological detection methods like immunohistochemistry.

Fig. 1: Staining of neurons in human brain using AA1R antibody SP4053

Fig. 2: Staining of neurons and glia in human brain using AA2AR antibody SP4054

Fig. 3: Staining of human kidney using AA3R antibody SP4055

Available Antibody Panel to Adenosine Receptors

Anti- Adenosine receptor A1 (AA1R, ADORA1), Adenosine receptor A2a (AA2AR, ADORA2A), Adenosine receptor A2b (AA2BR, ADORA2B), Adenosine receptor A3 (AA3R, ADORA3) antibody

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