SP7213P XAF1 (XIAP-associated factor 1) antibody
see related secondary antibodies
0.1 mg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti XAF1 (XIAP-associated factor 1) -
Synonyms
XAF-1 BIRC4BP XIAPAF1 BIRC4-binding protein
Product Description
Rabbit anti XAF1 (XIAP-associated factor 1) -, Presentation: Purified. Product is tested for Westernblot / Immunoblot ( WB ), Paraffin Sections ( P )
Properties
| Applications | Westernblot / Immunoblot ( WB ), Paraffin Sections ( P ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ) |
| Presentation | Purified |
| Host | Rabbit |
| Catalog Number | SP7213P |
| Swiss Prot. No. | Q6GPH4 |
| Quantity | 0.1 mg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP7213P.pdf |
Datasheet Extract
| Polyclonal Antibody to Human XAF1 (XIAP Associated Factor 1) | |
| Concentration | 0.5 mg/ml |
| Background | The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines. |
| Immunogen | A mixture of KLH-conjugated synthetic peptides corresponding to aa 201-218 and 301-317 of human XAF1 Swiss Num.: Q6GPH4 AA Sequence: NQTSTMEKDVRPKTRSIN / QLDLEKERYYKFKRFHF Remarks: GenBank no. CAA68030.1. |
| Format | State: Liquid Ig fraction Purification: Protein G Chromatography BufferSystem: PBS containing 0.02% sodium azide |
| Applications | Western blot: 1.0 - 2.0 µg/ml.
Immunohistochemistry (paraffin): 1/100. Recommended positive control: human liver (a 34 kDa band should be observed). |
| Specificity | This antibody is specific for XAF1. Species: Human, Mouse. |
| Storage | Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. |
| References | 1. Holcik M, Gibson H, Korneluk RG. Apoptosis 6(4): 253-261 (2001).
2. Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG. Nat Cell Biol 3(2): 128-133 (2001). 3. Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG. Genomics 70(1): 113-122 (2000). |
| Pictures | Western blot analysis of XAF1 in human liver lysates using SP7213P at 1 µg/ml.
|
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 170,00 € | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160,00 € | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160,00 € | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / 170,00 € | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170,00 € | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 200,00 € | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / 320,00 € | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / 320,00 € | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / 320,00 € | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / 320,00 € | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / 320,00 € | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / 330,00 € | |||||
Click here to see all secondary antibodies for 'SP7213P XAF1 (XIAP-associated factor 1)'.
