SP7001P 5-HT1D / HTR1D antibody
see related secondary antibodiessee all 17 5-HT1D / HTR1D products
0.1 mg / US$ 405
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti 5-HT1D / HTR1D
Synonyms
5-hydroxytryptamine Receptor 1D, 5-HT-1D
5-HT-1D-alpha, Serotonin receptor 1D, HTR1DA, HTRL, , 5-hydroxytryptamine (serotonin) receptor 1D, RDC4
Product review
Please read our product review about 5-HT1D / HTR1D : Antibodies to 5-hydroxytryptamine (Serotonin) Receptors.
Product Description
Rabbit anti 5-HT1D / HTR1D , Presentation: Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Purified |
| Host | Rabbit |
| Catalog Number | SP7001P |
| Swiss Prot. No. | P28221 |
| Quantity | 0.1 mg |
| Price | US$ 405 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP7001P.pdf |
Datasheet Extract
| Concentration | 0.5 mg/ml |
| Background | Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1,2). The 5-HT1D (formerly known as 5-HT1Da) receptor has 63% overall structural homology with the 5-HT1B receptor and a 77% amino acid sequence homology in the seven transmembrane domains (3). In situ hybridization studies have detected highest level of mRNA in primary olfactory cortex, accumbens nucleus, caudate putamen, lateral mammilary nucleus and medial vestibular nucleus (4). The presence of relatively high levels of 5-HT1D mRNA in the locus coeruleus suggest that, when expressed on nerve terminals, this receptor could modulate the release of catecholamines. The 5-HT1D receptor may function as an autoreceptor. Like 5-HT1B receptors, 5-HT1D receptors also appear to act as heteroreceptors. Acting on the 5-HT1D receptors, 5-HT appears to inhibit release of glutamate from rat cerebellar synaptosomes and acetylcholine from guinea pig hippocampal synaptosomes (5). It has been suggested that neurogenic inflammation and nociceptive activity within trigemino- vascular afferents. Endothelium-dependent relaxation in the pig coronary artery has been claimed to be mediated by 5-HT1D receptors (6). Like other members of the 5-HT1 family, 5-HT1D receptors are negatively coupled to adenylate cyclase. |
| Immunogen | Mixture of synthetic peptides corresponding to amino acids 1-18 and 251-267 of
rat 5-HT1DR (Genbank accession no. NP_036984) (7). Swiss Num.: P28221 |
| Format | State: Liquid purified Ig fraction Purification: Protein G chromatography BufferSystem: PBS containing 0.02% sodium azide |
| Applications | Western blotting (2 µg/ml).
A 40 kDa band is detected. |
| Specificity | This polyclonal antibody can be used for detection of 5-HT1DR in brain. Species: Human, mouse, and rat. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Petrouka, SJ. Trends Neurosci. 11: 486-500 (1998).
2. Lauder, JM. Trends Neurosci. 16: 233-240 (1993). 3. Weinshank, RL., Zgombick, JM., Macchi, MJ., Branchek, TA., Hartig, PR. Proc. Acad. Natl. Sci. USA 89: 3630-3633 (1992). 4. Gerhardt, CC. And van Heerikhuizen, H. Eur. J. Pharmacol. 334: 1-23 (1997). 5. Leonhardt, S., Herrick-Davis, K., Titeler, M. Proc. Natl. Acad. Sci. USA 89: 5517-5521 (1989). 6. Miller, KJ. And Teitker, M. Neurosci. Lett. 136: 223-226 (1992). 7. Hamblin,M.W., McGuffin,R.W., Metcalf,M.A., Dorsa, et al. Mol. Cell. Neurosci. 3, 578-587 (1992). |
| Pictures | Western blot analysis of 5-HT1DR in brain lysate with anti-5-HT1DR antibody(Cat.no.SP7001P). A protein band of approximate molecular weight of 40 kDa was detected.
|
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP7001P 5-HT1D / HTR1D '.
