SP5353P Voltage-gated potassium channel subunit Kv7.3 antibody
see related secondary antibodiessee all 2 Voltage-gated potassium channel subunit Kv7.3 products
0.1 mg / US$ 455
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti Voltage-gated potassium channel subunit Kv7.3
Synonyms
KCNQ3, Potassium channel subunit alpha KvLQT3, KQT-like 3, Potassium voltage-gated channel subfamily KQT member 3,
Product Description
Rabbit anti Voltage-gated potassium channel subunit Kv7.3 , Presentation: Aff - Purified. Product is tested for Frozen sections ( C ), Immunofluorescence ( IF ), Immunofluorescence ( IF )
Properties
| Applications | Frozen sections ( C ), Immunofluorescence ( IF ), Immunofluorescence ( IF ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP5353P |
| Swiss Prot. No. | O43525 |
| Quantity | 0.1 mg |
| Price | US$ 455 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP5353P.pdf |
Datasheet Extract
| Concentration | 1.0 mg/ml |
| Background | KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation.
Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. |
| Immunogen | GST fusion protein encoding the first 71 amino acids of rat KCNQ3. Swiss Num.: O43525 |
| Format | State: Liquid purified IgG fraction. Purification: Epitope affinity chromatography. BufferSystem: PBS with 1 mg/ml BSA as stabilizer and 0.02% sodium azide as preservative. |
| Applications | Immunofluorescence: 0.5 µg/ml.
Immunocytochemistry: 0.5 µg/ml. Immunohistochemistry on frozen sections: 0.5 µg/ml, staining using this antibody yielded a strong signal mainly in interneurons and astrocytes in the dentate region of rat hippocampal samples. |
| Specificity | SP5353P detects KCNQ3 from mouse, human and rat samples. This antibody is specific for KCNQ3 and does not detect KCNQ1, KCNQ2, KCNQ4 or KCNQ5. |
| Storage | Store the antibody at -20°C.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. British J. of Pharm., 137(8): 1173-1186, 2002.
|
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
