SP5193 TR alpha-1 / THRA1 / NR1A1 antibody
see related secondary antibodiessee all 3 TR alpha-1 / THRA1 / NR1A1 products
0.1 ml / US$ 455
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti TR alpha-1 / THRA1 / NR1A1
Synonyms
THRA , ,
Product review
Please read our product review about TR alpha-1 / THRA1 / NR1A1 : Antibody Panel to Thyroid Hormone Receptor (TR).
Product Description
Rabbit anti TR alpha-1 / THRA1 / NR1A1 , Presentation: Serum. Product is tested for Electrophoretic Mobility Shift Assay ( EMSA ), Immunofluorescence ( IF ), Western blot / Immunoblot ( WB )
Properties
| Applications | Electrophoretic Mobility Shift Assay ( EMSA ), Immunofluorescence ( IF ), Western blot / Immunoblot ( WB ) |
| Reactivity | Chicken ( Chk ), Human ( Hu ) |
| Presentation | Serum |
| Host | Rabbit |
| Catalog Number | SP5193 |
| Quantity | 0.1 ml |
| Price | US$ 455 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP5193.pdf |
Datasheet Extract
| Background | Thyroid hormone receptors (TR) are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively. TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge. TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1.
|
| Immunogen | Synthetic Peptide: E(403) V F E D Q E V(410) corresponding to amino acid residues 403-410 from human TR alpha-1. |
| Format | State: Liquid diluted antiserum BufferSystem: PBS containing 0.05% sodium azide |
| Applications | Gel shift (1/10): Gel shift experiments show that this product reacts with TR alpha-1 homodimers and TR alpha-1/retinoic X receptor (RXR) heterodimers.
Western blot (1/200): detects a 48 kDa protein representing recombinant human TR alpha-1 expressed in E. coli). Immunocytochemistry (1/200). |
| Specificity | SP5193 detects TR alpha-1. This antibody does not detect TRv alpha -2 or TR beta-1. Species: Human, chicken. |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. |
| References | Mol Endocrinology 18(7), 1631-1642, Jul 2004.
J. Clin. Endocrinol. Metab. Vol 87: 906-914, Feb 2002 |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP5193 TR alpha-1 / THRA1 / NR1A1 '.
