SP2146P Caspase-1 / CASP-1 (C-term.) antibody
see related secondary antibodiessee all 29 Caspase-1 / CASP-1 products
0.1 mg / US$ 485
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti Caspase-1 / CASP-1
Synonyms
CASP1, ICE, p45, IL-1BC, IL1BC, IL1BCE, , Caspase 1, Caspase1, CASP 1, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme
Product review
Please read our product review about Caspase-1 / CASP-1: Antibodies to Caspase Family.
Product Description
Rabbit anti Caspase-1 / CASP-1 , Presentation: Purified. Product is tested for Paraffin Sections ( P ), Western blot / Immunoblot ( WB )
Properties
| Applications | Paraffin Sections ( P ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Purified |
| Host | Rabbit |
| Catalog Number | SP2146P |
| Swiss Prot. No. | P29466 |
| Quantity | 0.1 mg |
| Price | US$ 485 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP2146P.pdf |
Datasheet Extract
| Alternate names | IL-1 Beta Converting Enzyme |
| Concentration | 1.0 mg/ml |
| Background | Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to
C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases. |
| Immunogen | A 16 amino acid peptide located near human Caspase-1 carboxy terminus. Swiss Num.: P29466 |
| Format | State: Liquid purified IgG Purification: Affinity chromatography BufferSystem: PBS containing 0.02% Sodium Azide |
| Applications | Western Blot: 0.5µg - 1.0µg/ml.
Immunohistochemistry on paraffin sections: 0.5µg - 1.0µg/ml; This product does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining. Recommended Positive Control: Human heart tissue. |
| Specificity | This antibody recognises an epitope within the C-terminal region (CT) of Caspase-1, otherwise known as IL-1Beta converting enzyme. This antibody detects a cleaved subunit band of approximately 21 kDa in heart cell lysates (predicted precursor MWT 45.2kDa). Species: Human. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Ghayur, T. et al. (1997) Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFNgamma production. Nature. 386: 619-623.
2. Fantuzzi, G. et al. (1998) Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta- converting enzyme (Capase-1)-deficient mice. Blood. 91: 2118-2125. 3. Kostura, M.J. et al. (1989) Identification of a monocyte specific pre-interleukin 1beta convertase activity. P.N.A.S USA 86: 5227-5231. 4. Miura, M. et al. (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell. 75: 653-660. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP2146P Caspase-1 / CASP-1'.
