SM7123P Caspase-1 / CASP-1 antibody
see related secondary antibodiessee all 29 Caspase-1 / CASP-1 products
0.1 mg / US$ 425
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse anti Caspase-1 / CASP-1 14F468
Synonyms
CASP1, ICE, p45, IL-1BC, IL1BC, IL1BCE, , Caspase 1, Caspase1, CASP 1, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme
Product review
Please read our product review about Caspase-1 / CASP-1: Antibodies to Caspase Family.
Product Description
Mouse anti Caspase-1 / CASP-1 14F468, Presentation: Purified. Product is tested for Paraffin Sections ( P ), Western blot / Immunoblot ( WB )
Properties
| Applications | Paraffin Sections ( P ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Purified |
| Host | Mouse |
| Isotype | IgG1 |
| Clone | 14F468 |
| Catalog Number | SM7123P |
| Swiss Prot. No. | P29466 |
| Quantity | 0.1 mg |
| Price | US$ 425 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SM7123P.pdf |
Datasheet Extract
| Concentration | 0.5 mg/ml |
| Background | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor. |
| Immunogen | Synthetic peptide corresponding to amino acids 371-390 of human caspase-1 Swiss Num.: P29466 AA Sequence: RKVRFSFEQPDGRAQMPTTE |
| Format | State: Liquid Ig fraction Purification: Protein G chromatography BufferSystem: PBS containing 0.2 % gelatin and 0.05 % sodium azide |
| Applications | Western blot (0.5-2 µg/ml).
Immunohistochemistry on paraffin embedded sections. Recommended Positive Control: HeLa or NIH 3T3 (a 45 kDa band is observed). |
| Specificity | This antibody is specific for Caspase-1. Species: Human, Mouse, Rat. |
| Storage | Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing. Centrifuge vial before opening. Shelf life: One year from despatch. |
| References | 1. Cerretti DP, et al. Science 256:97-100 (1992).
2. Yuan J, et al. Cell 75: 641-652 (1993). 3. Li PH, et al. Cell 80:401-411 (1995). 4. Tatsuta T. et al. J. Bio.Chem. 275:14248-54 (2000). |
| Pictures | Formalin-fixed, paraffin-embedded sections of human colon cancer stained for caspase-1 expression (SM7123P) using a DAB chromogen and Hematoxylin counterstain. 9 sections, from different human patients were stained. Differential staining was observed (top right panel). Two of these sections are shown at higher magnifications (arrows and A, B). Only rare staining in A is observed. In contrast, abundant staining is observed in B.
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14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SM7123P Caspase-1 / CASP-1'.
