SM3131A CD261 / TNFRSF10A antibody
see related secondary antibodiessee all 50 CD261 / TNFRSF10A products
0.1 mg / US$ 325
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse anti CD261 / TNFRSF10A DR-4-02
Synonyms
TNFRSF10A, APO2, DR4, TRAILR1, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, CD261, , Tumor necrosis factor receptor superfamily member 10A
Product Description
Mouse anti CD261 / TNFRSF10A DR-4-02, Presentation: Azide Free. Product is tested for Flow cytometry ( F ), Functional assay ( FN ), Immunofluorescence ( IF ), Immunoprecipitation ( IP )
Properties
| Applications | Flow cytometry ( F ), Functional assay ( FN ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ) |
| Reactivity | Human ( Hu ) |
| Presentation | Azide Free |
| Host | Mouse |
| Isotype | IgG1 |
| Clone | DR-4-02 |
| Catalog Number | SM3131A |
| Swiss Prot. No. | O00220 |
| Quantity | 0.1 mg |
| Price | US$ 325 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SM3131A.pdf |
Datasheet Extract
| Alternate names | DR4, TRAIL-R1 |
| Concentration | 1.0 mg/ml |
| Background | TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.
Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor). |
| Immunogen | Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1 Swiss Num.: O00220 |
| Format | State: Liquid purified Ig fraction. Purity > 95% (by SDS-PAGE) Purification: Protein A affinity chromatography BufferSystem: Azide free PBS, preserved by filter sterilization, approx. pH 7.4 |
| Applications | Flow cytometry (3-5 µg/ml).
Immunoprecipitation. Immunocytochemistry. Functional application: Soluble antibody DR-4-02 blocks apoptosis triggered by a ligand (TRAIL). Plastic-immobilized (cross-linked) DR-4-02 antibody induces apoptosis in sensitive cells. Recommended dilution of antibody: 2-3 µg/ml in cultivation medium. Final concentration of TRAIL: 20-200 ng/ml. Application note: It is recommended to add the antibody 15 min before addition of TRAIL. |
| Specificity | The antibody recognizes TRAIL-R1, a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines. Species: Human. |
| Storage | Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36. |
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SM3131A CD261 / TNFRSF10A'.
