SM2048P LAIR-1 (CD305) antibody
see related secondary antibodiessee all 16 LAIR-1 products
0.2 mg / US$ 565
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse anti LAIR-1 (CD305) NKTA255
Synonyms
LAIR1, NK Cell Marker,
Product Description
Mouse anti LAIR-1 (CD305) NKTA255, Presentation: Aff - Purified. Product is tested for Flow cytometry ( F ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Flow cytometry ( F ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Mouse |
| Isotype | IgG1 |
| Clone | NKTA255 |
| Catalog Number | SM2048P |
| Quantity | 0.2 mg |
| Price | US$ 565 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SM2048P.pdf |
Datasheet Extract
| Monoclonal Antibody to Human LAIR-1 | |
| Alternate names | CD305 |
| Concentration | 1.0 mg/ml |
| Background | LAIR-1 is a 40kD cell surface molecule that functions as an inhibitory receptor on natural killer cells, monocytes and T cells. LAIR-1, otherwise known as CD305, is also expressed by other haematopoeitic cells including B cells, but is not expressed by nonhaematopoietic, platelets or erythrocytes. |
| Immunogen | NK cells lines B12.100 and AM.25. Spleen cells from immunised mice were fused with cells of the P3U1 myeloma cell line. |
| Format | State: Liquid purified IgG Purification: Affinity chromatography on Protein G BufferSystem: PBS, pH7.4 containing 0.09% Sodium Azide |
| Applications | Flow Cytometry: 1/50 - 1/100; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
Immunoprecipitation. Western Blot: this antibody detects a band of approximately 40 kDa. |
| Specificity | This antibody recognises leukocyte-associated Ig-like receptor-1 (LAIR-1). Clone NKTA255 is reported to inhibit NK cell triggering via CD16 molecules. We recommend the use of SM2048A for this purpose. Species: Human. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Poggi, A. et al. (1995) p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur. J. Immunol. 25: 369 - 376.
2. Zocchi, M. R. et al. (2001) Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur. J. Immunol. 31: 3667 - 3675. 3. Poggi, A. et al. (2000) Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents nuclear translocation in human myeloid leukemias. Eur. J. Immunol. 30: 2751 - 2758. |
| Pictures | Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD305(SM2048P). |
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SM2048P LAIR-1 (CD305)'.