Human Bone Morphogenetic Protein 13 (BMP13) PA213X - antibody, protein, elisa from Acris Antibodies ...

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see all 7 Bone Morphogenetic Protein 13 products

50 µg / US$ 355

NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com

Human Bone Morphogenetic Protein 13 (BMP13)

BMP-13, CDMP2,

Human Bone Morphogenetic Protein 13 (BMP13)


Background	BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains.
Source	E.coli
Format	*State:* Lyophilized *Purity:* Greater than 95% by SDS-PAGE. *Endotoxinlevel:* < 0.1 ng per �g (1EU/�g).
Description	This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. *AASequence:* TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR *Biological Activity:* The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 �g/ml.
Storage	The lyophilized protein is stable for one month at room temperature, but best stored at -20°C. Reconstituted BMP-13/CDMP-2 should be stored in working aliquots at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from desptach.


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