PA137X BLC / CXCL13 antigen
see all 18 BLC / CXCL13 products
20 µg / US$ 355
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human BLC / CXCL13
Synonyms
CXC Chemokine BLC BCA1 BCA-1 SCYB13 ANGIE C-X-C Motif Chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, B cell-attracting chemokine 1
Product Description
Human BLC / CXCL13 ;Is tested for Flow cytometry (F)
Properties
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 10.1 kD |
| Catalog Number | PA137X |
| Swiss Prot. No. | O43927 |
| Quantity | 20 µg |
| Price | US$ 355 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA137X.pdf |
Datasheet Extract
| Recombinant Human BCA-1/BLC (CXCL13) | |
| Alternate names | B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand
|
| Background | BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. |
| Immunogen | Swiss Num.: O43927 |
| Source | E. coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) without additives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant Human BCA-1 is a protein containing 87 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines. AASequence: VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP Biological Activity: Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml. Molecular weight: 10.3 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted BCA-1 should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Lim, H.W. Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells. The Journal of Immunology, 2008, 180(1):122-9.
2. Alejo A A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus Proc Natl Acad Sci U S A., 2006, 103(15):5995-6000. 3. Honczarenko M Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors Stem Cells, 2006, 24(4):1030-41. 4. Marek Honczarenko CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor Blood, 2002, Vol: 100 (7) pp. 2321-2329. 5. Michael Ticchioni Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration Blood, 2002, Vol: 99 (9) pp. 3111-3118. 6. Casamayor-Palleja M Expression of macrophage inflammatory protein-3a, stromal cell-derived factor-1, and B-cell-attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells Blood, 2001, Vol 97 (12) pp.3992-3994. |
