PA1334XC Hemopexin-like domain of MMP-2 (C-terminal) (445-635 a.a.) antigen
see all 3 Hemopexin-like domain of MMP-2 products
1 mg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Hemopexin-like domain of MMP-2 (C-terminal) (445-635 a.a.)
Synonyms
MMP2, CLG4A, Gelatinase A, TBE-1, 72 kDa type IV collagenase,
Product Description
Human Hemopexin-like domain of MMP-2 (C-terminal) (445-635 a.a.)
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >95% |
| Source | E. coli |
| Catalog Number | PA1334XC |
| Quantity | 1 mg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1334XC.pdf |
Datasheet Extract
| Concentration | 1,0 mg/ml |
| Source | E. coli |
| Format | State: Lyophilized purified protein (Sterile Filtered) Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel. BufferSystem: 2mM Tris pH-7.4 Reconstitution: Restore in sterile 18Mohm-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Description | Recombinant Human PEX is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity and can inhibit cell associated collagenolytic activity both in vitro and in vivo. Moreover, PEX can block angiogenesis and tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX is expressed as inclusion bodies in E. coli. AASequence: MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWLGC Biological Activity: The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Molecular weight: 28,453 dalton |
| Add. Information | Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm. 2. Analysis by RP-HPLC. |
| Storage | Prior to reconstitution store at RT for 3 weeks.
Following reconstitution store the protein undiluted at 2-8°C for one week or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Shelf life: one year from despatch. |