PA1265 Matrix Metalloproteinase-3 (MMP-3) antigen
see all 19 Matrix Metalloproteinase-3 products
5 µg / US$ 225
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Matrix Metalloproteinase-3 (MMP-3)
Synonyms
MMP3, STMY1, Stromelysin-1, SL-1, Transin-1,
Product Description
Human Matrix Metalloproteinase-3 (MMP-3)
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 22 kD |
| Catalog Number | PA1265 |
| Quantity | 5 µg |
| Price | US$ 225 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1265.pdf |
Datasheet Extract
| Alternate names | Stromelysin-1, EC 3.4.24.17, Transin-1 |
| Concentration | 1.0 mg/ml |
| Background | MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta.
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| Source | E. coli |
| Format | State: Sterile filtered white lyophilized powder containing no additives Purity: Purified by proprietary chromatographic techniques, purity is greater than 98% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE Reconstitution: Restore in sterile 18M?-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Description | Recombinant Human Matrix Metalloproteinase-3 is a single, non-glycosylated, polypeptide chain containing 230 amino acids. Specific Activity: >= 1,250 mU/mg protein (H. Nagase, et al; J. Biol. Chem. 269, 20952, 1994). Molecular weight: 22 kDa |
| Add. Information | One unit is defined as the amount of enzyme thathydrolyzes 1 µmol of MCA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)-NH2 per min. at 37 °C, pH 7.0. |
| Storage | Lyophilized product although stable at room temperature for 3 weeks, should be stored desiccated below -18 °C. Upon reconstitution it should be stored at 2 - 8 °C between 2 - 7 days and for future use below -18 °C. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA).
Please avoid freeze-thaw cycles. Shelf life: One year from despatch. |
