PA1264X Matrix Metalloproteinase-7 (MMP-7) (pro) antigen
see all 28 Matrix Metalloproteinase-7 products
20 µg / US$ 305
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Matrix Metalloproteinase-7 (MMP-7) (pro)
Synonyms
MMP7, Matrilysin, Matrin, MPSL1, PUMP1,
Product Description
Human Matrix Metalloproteinase-7 (MMP-7) (pro)
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >95% |
| Source | E. coli |
| Molecular Weight | 28 kD |
| Catalog Number | PA1264X |
| Quantity | 20 µg |
| Price | US$ 305 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1264X.pdf |
Datasheet Extract
| Alternate names | Matrilysin, PUMP |
| Concentration | 1 mg/ml |
| Background | Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas. |
| Source | E. coli |
| Format | State: Sterile clear liquid solution Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. BufferSystem: 25 mM Tris-HCl (pH 7.5),150 mM NaCl, 5 mM CaCl2, 0.01 % Brij-35 and 0.02 % NaN3 |
| Add. Information | The specific activity was found to be 1400 IU/mg.
One unit is defined as the digestion of 1 µg Azocoll/min at 37 °C. |
| Storage | ProMMP-7 although stable at 2 - 8 °C for 3 weeks, should be stored desiccated below -18 °C.
Please prevent freeze-thaw cycles. Shelf life: one year from despatch. |
