PA1263XC Matrix Metalloproteinase-7 (MMP-7) antigen
see all 28 Matrix Metalloproteinase-7 products
1 mg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Matrix Metalloproteinase-7 (MMP-7)
Synonyms
MMP7, Matrilysin, Matrin, MPSL1, PUMP1,
Product Description
Human Matrix Metalloproteinase-7 (MMP-7)
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >95% |
| Source | E. coli |
| Molecular Weight | 19 kD |
| Catalog Number | PA1263XC |
| Quantity | 1 mg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1263XC.pdf |
Datasheet Extract
| Alternate names | Matrilysin, EC 3.4.24.23, Pump-1 protease, Uterine metalloproteinase, Matrix metalloproteinase-7, MMP-7, Matrin, MPSL1, PUMP-1 |
| Concentration | 0.83 mg/ml |
| Background | Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas. |
| Source | E. coli |
| Format | State: Sterile clear liquid solution Purity: Purified by proprietary chromatographic techniques, purity is greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. BufferSystem: 10 mM HEPES (pH 7.4), 5 mM CaCl2 and 150 mM NaCl |
| Description | Recombinant Matrix Metalloproteinase-7 is a single, non-glycosylated, polypeptide chain.
Specific Activity: 3100 IU/mg Molecular weight: 19.13 kDa |
| Add. Information | One unit is defined as the digestion of 1 µg Azocoll/min at 37 °C. |
| Storage | Product is stable at 2 - 8 °C for 3 weeks, should be stored desiccated below -18 °C.
Please avoid freeze thaw cycles. Shelf life: One year from despatch. |
| References | Harder et al (1997) Nature 387, 861; Ganz T (1999) Science 286, 420
Yang D et al (1999) Science 286, 525 Wilson CL et al (1999) Science 286, 113-117 Cottman DW et al (1993) Intl J. Oncol. 2, 861-872 Wossner JF et al (1995) Methods Enzymol. 248, 485-495 Imai K et al (1995) J. Biol. Chem. 269, 2032-2040 Brunner KL et al (1995) Proc. Natl. Acad. Sci. 92, 7362-7366 |
