PA1140XC Eotaxin / CCL11 antigen
see all 27 Eotaxin / CCL11 products
1 mg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Eotaxin / CCL11
Synonyms
C-C motif chemokine 11, Small-inducible cytokine A11, Eosinophil chemotactic protein, SCYA11,
Product Description
Human Eotaxin / CCL11
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 8 kD |
| Catalog Number | PA1140XC |
| Swiss Prot. No. | P51671 |
| Quantity | 1 mg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1140XC.pdf |
Datasheet Extract
| Alternate names | Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11, MGC22554 |
| Concentration | 1,0 mg/ml |
| Background | Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17. |
| Immunogen | Swiss Num.: P51671 |
| Source | Escherichia Coli |
| Format | State: Lyophilized purified protein (sterile filtered) Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. Reconstitution: Restore in sterile 18Mohm-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Description | Eotaxin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids. The CCL11 is purified by proprietary chromatographic techniques.
AASequence: The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Pro-Ala-Ser-Val. Biological Activity: The activity is determined by the chemoattract of human PBE (peripheral blood eosinophils) at a concentration between 0.1-10 ng/ml. Molecular weight: 8345.9 Dalton |
| Add. Information | Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 1.013 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of Eotaxin as a Reference Standard. |
| Storage | Prior to reconstitution stable at RT for 3 weeks.
Following reconstitution store the protein undiluted at 2-8°C for one week or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Shelf life: one year from despatch. |
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