PA101X Macrophage Chemotactic Protein-4 (MCP-4) (NCC-1) antigen
see all 11 Macrophage Chemotactic Protein-4 products
10 µg / US$ 355
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Macrophage Chemotactic Protein-4 (MCP-4) (NCC-1)
Synonyms
MCP4 NCC1 CCL13
Product Description
Human Macrophage Chemotactic Protein-4 (MCP-4) (NCC-1) ;Is tested for Flow cytometry (F)
Properties
| Species | Human |
| Purity | >95% |
| Source | E. coli |
| Molecular Weight | 8.6 kD |
| Catalog Number | PA101X |
| Quantity | 10 µg |
| Price | US$ 355 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA101X.pdf |
Datasheet Extract
| Recombinant Human MCP-4 (CCL13) | |
| Alternate names | Monocyte Chemotactic Protein-4, CCL13, NCC-1
|
| Background | The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. |
| Source | E. coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) wit no preservatives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant murine MCP-2 is a protein containing 75 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. AASequence: QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration of 10.0-100.0 ng/ml. Molecular weight: 8.6 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted MCP-4 should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Lim H.W. Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells. Journal of Immunology, 2006, 177(2):840-51.
2.Mateo T Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines J Immunol., 2006, 176(9):5577-86. 3. Jose Miguel Rodriguez-Frade Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor The EMBO J., 2004, Vol: 23 (1) pp. 66-76. 4. Liwen Zhang Functional expression and characterization of macaque C-C chemokine receptor 3 (CCR3) and generation of potent antagonistic anti-macaque CCR3 monoclonal antibodies J. Biol. Chem., 2002, Vol: 277 (37) pp. 33799-33810. 5. Anja Mueller Pathways for internalization and recycling of the chemokine receptor CCR5 Blood, 2002, Vol: 99 (3) pp. 785-791. 6. Sabroe I A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3 J. Biol. Chem., 2000, Volume 275. Issue 34. Pp.25985-25992. 7. Kitaura M Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3*- J.Biol. Chem., 1999, Volume 274. Issue 39. Pp.27975-27980. 8. Gerszten RE MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions Nature, 1999, Volume 398. 9. Sabroe I Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways1 The Journal of Immunology, 1999, 162: pp.2946-2955. 10. Tiffany HL Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309 J. Exp. Med., 1997, Volume 186. Number 1. Pp.165-170. |
