PA100X Macrophage Chemotactic Protein-3 (MCP-3) antigen
see all 21 Macrophage Chemotactic Protein-3 products
10 µg / US$ 355
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Macrophage Chemotactic Protein-3 (MCP-3)
Synonyms
MCP3 CCL7
Product Description
Human Macrophage Chemotactic Protein-3 (MCP-3) ;Is tested for Flow cytometry (F)
Properties
| Species | Human |
| Purity | >99% |
| Source | E. coli |
| Molecular Weight | 9 kD |
| Catalog Number | PA100X |
| Quantity | 10 µg |
| Price | US$ 355 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA100X.pdf |
Datasheet Extract
| Recombinant Human MCP-3 (CCL7) | |
| Alternate names | Monocyte Chemotactic Protein-3, CCL7, MARC
|
| Background | The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. |
| Source | E. coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) wit no preservatives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use |
| Description | Recombinant human MCP-3 is a protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. AASequence: QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml. Molecular weight: 9.0 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted MCP-3 should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Mateo T, A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles Blood, 2007, 110(6):1895-902.
2. Fox, J.M. Structure/Function Relationships of CCR8 Agonists and Antagonists: AMINO-TERMINAL EXTENSION OF CCL1 BY A SINGLE AMINO ACID GENERATES A PARTIAL AGONIST. Journal of Biological Chemistry, 2006, 281(48):36652-61. 3. Van den Steen PE The Hemopexin and O-Glycosylated Domains Tune Gelatinase B/MMP-9 Bioavailability via Inhibition and Binding to Cargo Receptors. J Biol Chem., 2006, 281(27):18626-37. 4. Mateo T Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines J Immunol., 2006, 176(9):5577-86. 5. Hirata T Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus Journal of Biological Chemistry, 2004, 10;279(50):51775-82. |
