PA099X Macrophage Chemotactic Protein-2 (MCP-2) antigen
see all 13 Macrophage Chemotactic Protein-2 products
10 µg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Macrophage Chemotactic Protein-2 (MCP-2)
Synonyms
MCP2 CCL8
Product Description
Human Macrophage Chemotactic Protein-2 (MCP-2) ;Is tested for Flow cytometry (F)
Properties
| Species | Human |
| Purity | >99% |
| Source | E. coli |
| Molecular Weight | 8.9 kD |
| Catalog Number | PA099X |
| Quantity | 10 µg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA099X.pdf |
Datasheet Extract
| Recombinant Human MCP-2 (CCL8) | |
| Alternate names | Monocyte Chemotactic Protein-2, CCL8, HC14
|
| Background | The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. |
| Source | E. coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) wit no preservatives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant human MCP-2 is a protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. AASequence: QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml. Molecular weight: 8.9 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted MCP-2 should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Hirata T Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus Journal of Biological Chemistry, 2004 Dec 10;279(50):51775-82.
2. Diana Alvarez Arias Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2 J. Bio. Chem., 2003, Vol: 278 (38) pp. 36513-36521. 3. Anja Mueller Pathways for internalization and recycling of the chemokine receptor CCR5 Blood, 2002, Vol: 99 (3) pp. 785-791. 4. Schweickart VL CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines* The Journal of Biological Chemistry, 2000, Volume 275. Number 13. Pp.9550-9556. 5. Oppermann M Differential Effects of CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus*- J. Biol Chem., 1999, Volume 274, Issue 13. pp. 8875-8885. 6. Bodaghi B Chemokine Sequestration by Viral Chemoreceptors as a Novel Viral Escape Strategy: Withdrawal of Chemokines from the Environment of Cytomegalovirus-infected Cells J. Exp. Med. The Rockefeller University Press., 1998, Volume 188. Number 5. Pp.855-866. 7. Wang JM HIV-1 Envelope gp120 Inhibits the Monocyte Response to Chemokines Through CD4 Signal-Dependent Chemokine Receptor Down-Regulation1 The Journal of Immunology, 1998, 161: pp.4309-4317. 8. Oravecz T Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cells Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage J. Exp.Med., 1997, Volume 186, Number 11. Pp.1865-1872. |
