PA022X KC/CINC antigen
see all 12 KC/CINC products
20 µg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse KC/CINC
Product Description
Mouse KC/CINC ;Is tested for Flow cytometry (F)
Properties
| Species | Mouse |
| Purity | >99% |
| Source | E. coli |
| Molecular Weight | 7.8 kD |
| Catalog Number | PA022X |
| Quantity | 20 µg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA022X.pdf |
Datasheet Extract
| Recombinant Murine KC/CINC | |
| Alternate names | CXCL1, GRO alpha, NAP-3, GRO1, CINC (rat)
|
| Background | All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. |
| Source | E.coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) without additives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant murine KC is a protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. AASequence: APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK Biological Activity: Determined by its ability to chemoattract total human neutrophil population using a concentration range of 10.0-100.0 ng/ml. Molecular weight: 7.8 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted Murine KC should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Wengner AM, The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation, Blood, 2008, 111(1):42-9.
2. Pinho, V., Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo. The Journal of Immunology, 2007, 179(11):7891-8. 3. Zarbock A, Galphai2 is required for chemokine-induced neutrophil arrest, Blood, 2007, 110(10):3773-9. 4. Tsuruta, Y. Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. The Journal of Immunology, 2007, 179(10):7079-86. 5. Yu JJ, An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals, Blood, 2007, 109(9):3794-802. |
