PA020X C-C motif chemokine 2 antigen
see all 56 C-C motif chemokine 2 products
10 µg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse C-C motif chemokine 2
Synonyms
CCL2 CCL-2 MCP1 SCYA2 Small-inducible cytokine A2 Monocyte chemoattractant protein 1 Monocyte chemotactic protein 1 MCP-1 Monocyte chemotactic and activating factor MCAF Monocyte secretory protein JE HC11
Product Description
Mouse C-C motif chemokine 2 ;Is tested for Flow cytometry (F)
Properties
| Species | Mouse |
| Purity | >99% |
| Source | E. coli |
| Molecular Weight | 13.8 kD |
| Catalog Number | PA020X |
| Quantity | 10 µg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA020X.pdf |
Datasheet Extract
| Recombinant Murine JE | |
| Alternate names | Monocyte Chemotactic Protein-1 (MCP-1), CCL2 |
| Background | The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. |
| Source | E. coli |
| Format | State: Sterile filtered and lyophilized with no additives. Purity: > 98% pure by SDS-PAGE and HPLC analyses Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Centrifuge the vial prior to opening! Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant murine JE is a protein containing 125 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. AASequence: QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN Biological Activity: Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1.0-20.0 ng/ml. Specific Activity: 13.8 kDa |
| Storage | The lyophilized protein is stable at -20°C for one year from date of despatch.
Reconstituted JE is stable for 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. |
| References | 1. Pacheco, P. Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 Controls Microtubule-Driven Biogenesis and Leukotriene B4-Synthesizing Function of Macrophage Lipid Bodies Elicited by Innate Immune Response. The Journal of Immunology, 2007, 179(12):8500-8.
2. Diaz-Guerra, E. CCL2 Inhibits the Apoptosis Program Induced by Growth Factor Deprivation, Rescuing Functional T Cells. The Journal of Immunology, 2007, 179(11):7352-7. 3. Zelcer, N. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proceedings of the National Academy of Sciences of the U S A., 2007, 104(25):10601-6. 4. Thompson, B.D. Inhibition of G{alpha}i2 Activation by G{alpha}i3 in CXCR3-mediated Signaling. The Journal of Biological Chemistry, 2007, 282(13):9547-55. 5. Herold S. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. Journal of Immunology, 2006, 177(3):1817-24. |
