NB400-142 CD220 / INSR / Insulin Receptor alpha antibody
see related secondary antibodiessee all 8 CD220 / INSR / Insulin Receptor alpha products
0.1 ml / US$ 435 no delivery possible
Quick Overview
Mouse anti CD220 / INSR / Insulin Receptor alpha MA-20
Synonyms
INSR, CD220, IR, EC 2.7.10.1, Insulin receptor, , IGFR1, Insulin growth factor 1 receptor, CD221
Product review
Please read our product review about CD220 / INSR / Insulin Receptor alpha : Antibody Panel to Insulin Receptor (CD220).
Product Description
Mouse anti CD220 / INSR / Insulin Receptor alpha MA-20, Presentation: Purified. Product is tested for Functional assay ( FN ), Immunoprecipitation ( IP )
Properties
| Applications | Functional assay ( FN ), Immunoprecipitation ( IP ) |
| Reactivity | Human ( Hu ) |
| Presentation | Purified |
| Host | Mouse |
| Isotype | IgG2b |
| Clone | MA-20 |
| Catalog Number | NB400-142 |
| Swiss Prot. No. | P06213 |
| Quantity | 0.1 ml |
| Price | US$ 435 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet | view  NB400-142.pdf |
Datasheet Extract
| Mouse Monoclonal anti-Insulin Receptor (MA-20) | |
| Alternate names | anti-INSR antibody; anti-Insulin receptor subunit alpha antibody; anti-CD220 antibody |
| Concentration | 1.2 mg/ml |
| Background | The insulin receptor is functionally important for negative cooperativity, down-regulation, and beta-subunit tyrosine kinase activity. There are two recognized epitopes of the alpha-subunit. One epitope is close to the insulin-binding site and plays a role in insulin-induced negative cooperativity and down-regulation. The other site (recognized by the monoclonal MA-20 antibody) is at a distance from the insulin-binding site, where it only plays a role in down-regulation. Both epitopes appear to be independent of insulin receptor tyrosine kinase activity. |
| Immunogen | Highly purified insulin receptors (alpha-subunit) from human term placentas. Swiss Num.: P06213 |
| Format | Purification: Affinity purified Purity: Affinity purified BufferSystem: 10 mM phosphate buffer [pH 7.4], 100 mM NaCl. |
| Applications | ELISA , immunoprecipitation , Competition Assay |
| Specificity | Species: Human. Other species have not been tested. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Forsayeth, J.R., et al. Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation. <i>JBC.</i> <b>262(9):</b> 4134-4140, 1987. (Immunoprecipitation, Compet. assay, human)
2. Frasca, F., et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Molec. & Cell. Biol. 19(5):3278-3288, 1999. (ELISA, Immunoprecipitation, Western Blot, Human) 3. Federici, M., et al. Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects. J. Clin. Invest. 98(12):2887-2893, 1996. (Western Blot, Human) 4. Li, M., et al. Small molcule insulin receptor activators potentiate insulin action in insulin-resistant cells. Diabetes. 50:2323-2328, 2001. (ELISA, Western Blot, Rat) |
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB400-142 CD220 / INSR / Insulin Receptor alpha '.
