NB400-102 Scavenger Receptor Class B Type II (SR-BII) antibody
see related secondary antibodies
0.1 ml / US$ 435 no delivery possible
Quick Overview
Rabbit anti Scavenger Receptor Class B Type II (SR-BII)
Synonyms
SRBII,
Product Description
Rabbit anti Scavenger Receptor Class B Type II (SR-BII) , Presentation: Serum. Product is tested for Immunofluorescence ( IF ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunofluorescence ( IF ), Western blot / Immunoblot ( WB ) |
| Reactivity | Rat ( Rt ), Bovine ( Bov ), Hamster ( Hst ) |
| Presentation | Serum |
| Host | Rabbit |
| Catalog Number | NB400-102 |
| Quantity | 0.1 ml |
| Price | US$ 435 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet | view  NB400-102.pdf |
Datasheet Extract
| Rabbit Polyclonal anti-SR-BII | |
| Alternate names | anti-SR-B2 antibody, anti-SR-BII antibody, anti-Scavenger Receptor-BII antibody, anti-Scavenger Receptor-B2 antibody |
| Background | High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes.
Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells. (1-6) |
| Immunogen | A peptide containing residues from mouse SR-BII (2). |
| Format | BufferSystem: serum |
| Applications | immunofluorescence 1:500- 1:1000, Western Blot 1:1000, Immunohistochemistry-Paraffin 1:25 |
| Specificity | Species: Mouse, rat, bovine, human, mink and hamster SR-BII. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. NR Webb, et al. SR-BII, an Isoform of the Scavenger Receptor BI Containing an Alternate Cytoplasmic Tail, Mediates Lipid Transfer between High Density Lipoprotein and Cells. J. of Biol. Chem. 273(24): 15241-15248, 1998.
2. NR Webb, et al. Alternative forms of the scavenger receptor B1 (SR-B1). J. Lipid Research, 38: 1490-1495, 1997. 3. M. Krieger. The best of cholesterols the worst of cholesterols: A tale of two receptors. Proc. Natl. Acad. Sci. 95: 4077-4080, 1988. 4. S. Acton et al. Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor. Science. 271: 518-520, 1996. 5. Rigotti et al. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. PNAS. 94: 12610-12615, 1997. 6. RE Temel et al. Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidgenic pathway in cultured mouse adrenocortical cells. PNAS. 94: 13600-13605, 1997. 1. Huby, T., Doucet, C., Dachet, C., Ouzilleau, B., Ueda, Y., Afzal, V., Rubin, E., Chapman, M. J., and Lesnik, P. (2006) Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues, 116, 2767-2776. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
