NB400-101 Scavenger Receptor Class B Type I (SR-BI) antibody
see related secondary antibodiessee all 3 Scavenger Receptor Class B Type I products
0.1 ml / US$ 435 no delivery possible
Quick Overview
Rabbit anti Scavenger Receptor Class B Type I (SR-BI)
Synonyms
SRBI,
Product Description
Rabbit anti Scavenger Receptor Class B Type I (SR-BI) , Presentation: Serum. Product is tested for Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Rat ( Rt ), Hamster ( Hst ) |
| Presentation | Serum |
| Host | Rabbit |
| Catalog Number | NB400-101 |
| Quantity | 0.1 ml |
| Price | US$ 435 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet | view  NB400-101.pdf |
Datasheet Extract
| Rabbit Polyclonal anti-SR-BI | |
| Alternate names | anti-SCARB1 antibody; anti-SR-B1 antibody; anti-SR-BI antibody; anti-Scavenger Receptor-BI antibody; anti-Scavenger Receptor-B1 antibody |
| Background | High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. |
| Immunogen | A peptide containing residues 496-509 from mouse SR-BI plus an N-terminal cysteine was coupled to KLH. CSPAAKGTVLQEAKL-COOH. |
| Format | Purification: Whole antisera Purity: Whole antisera BufferSystem: n/a |
| Applications | flow cytometry / FACS analysis , immunoprecipitation 4-8 ug/ml lysate, Western Blot 1:1000 |
| Specificity | Species: Reacts with mouse, rat human, and hamster SR-BI. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. NR Webb, et al. SR-BII, an Isoform of the Scavenger Receptor BI Containing an Alternate Cytoplasmic Tail, Mediates Lipid Transfer between High Density Lipoprotein and Cells. J. of Biol. Chem. 273(24): 15241-15248, 1998.
2. P. Svensson, et al. Scavenger Receptor Class B Type I in the Rat Ovary : Possible Role in High Density Lipoprotein Cholesterol Uptake and in the Recognition of Apoptotic Granulosa Cells. Endocrinology. 140(6): 2494-2500, 1999. 3. NR Webb, et al. Alternative forms of the scavenger receptor B1 (SR-B1). J. Lipid Research, 38: 1490-1495, 1997. 4. M. Krieger. The best of cholesterols the worst of cholesterols: A tale of two receptors. Proc. Natl. Acad. Sci. 95: 4077-4080, 1988. 5. S. Acton et al. Identification of SR-BI as a High Density Lipoprotein Receptor. Science. 271: 518-520, 1996. 6. Rigotti et al. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. PNAS. 94: 12610-12615, 1997. 7. RE Temel et al. Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidgenic pathway in cultured mouse adrenocortical cells. PNAS. 94: 13600-13605, 1997. 8. Wyss-Coray, T., et al. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nature Medicine. 9:453-457, 2003. 9. Kramer, W., et al. Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane. Biochimica et Biophysica Acta 1633. 13-36, 2003. 10. Khovidhunkit, W., Regulation of scavenger receptor class B type I in hamster liver and Hep3B cells by endotoxin and cyokines. Lournal of Lipid Research. 42: 1636-1644, 2001. 1. Zhang, Y., Ahmed, A.M., McFarlane, N., Capone, C., Boreham, D.R., Truant, R., Igdoura, S.A. and Trigatti, B.L. (2007) Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways, J. Lipid Res., 48, 405-416. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB400-101 Scavenger Receptor Class B Type I (SR-BI)'.
