NB300-615 Androgen Receptor / AR antibody
see related secondary antibodiessee all 39 Androgen Receptor / AR products
50 µg / US$ 485 no delivery possible
Quick Overview
Rat anti Androgen Receptor / AR AN1-15
Synonyms
Dihydrotestosterone Receptor, DHTR, NR3C4, , Nuclear receptor subfamily 3 group C member 4, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease, AIS, HUMARA, KD, SBMA, SMAX1, TFM
Product review
Please read our product review about Androgen Receptor / AR : Antibodies to Androgen Receptor.
Product Description
Rat anti Androgen Receptor / AR AN1-15, Presentation: Ig Fraction. Product is tested for Frozen sections ( C ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Frozen sections ( C ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Monkey ( Mky ), Rat ( Rt ) |
| Presentation | Ig Fraction |
| Host | Rat |
| Isotype | IgG |
| Clone | AN1-15 |
| Catalog Number | NB300-615 |
| Swiss Prot. No. | P10275 |
| Quantity | 50 µg |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Rat Monoclonal anti-Androgen Receptor (AN1-15) | |
| Alternate names | anti-AR antibody, anti-KD antibody, anti-AIS antibody, anti-TFM antibody, anti-DHTR antibody, anti-SBMA antibody, anti-NR3C4 antibody, anti-SMAX1 antibody, anti-HUMARA antibody, anti-androgen receptor (dihydrotestosterone receptor testicular feminization spinal and bulbar muscular atrophy Kennedy disease) antibody, anti-dihydrotestosterone receptor antibody, anti-AIS antibody, anti-AR antibody, anti-DHTR antibody, anti-Dihydro Testosterone Receptor antibody, anti-dihydrotestosterone receptor antibody, anti-HUMARA KD antibody, anti-NR3C4 antibody, anti-SBMA antibody, anti-SMAX1 antibody, anti-TFM antibody |
| Background | Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain.
The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis. |
| Immunogen | A 241 amino acid fusion protein derived from human androgen receptor. Swiss Num.: P10275 |
| Format | Purification: IgG purified Purity: IgG purified BufferSystem: PBS |
| Applications | immunohistochemistry 4 µg/ml, immunoprecipitation Assay dependent, Western Blot 1 µg/ml, Immunocytochemistry 5 µg/ml, Gel Super Shift Assays Assay dependent |
| Specificity | Species: Cross-reacts with Human, Rat, Mouse and Primate. Not yet tested in other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | This product has been used in:Morvillo V et al. Atypical androgen receptor in the human melanoma cell line IIB-MEL-J. Pigment Cell Res 8:135-41 (1995). |
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1371B | Rat IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 295 | |||||
| R1371F | Rat IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1371T | Rat IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1371TR | Rat IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1371HRP | Rat IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1371AP | Rat IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 335 | |||||
| R1439C2 | Rat IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1439C3 | Rat IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1439C35 | Rat IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1439C5 | Rat IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1439C55 | Rat IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1413R | Rat IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Ms, Rb, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1428R | Rat IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
| R1415R | Rat IgG F(ab')2 F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
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