NB200-525 p53 (K373/K382-Acetylated) (aa. 368-389) antibody
see related secondary antibodiessee all 282 p53 products
50 µl / US$ 485 no delivery possible
Quick Overview
Rabbit anti p53
Synonyms
Phosphoprotein p53, TP53, NY-CO-13, TRP53, , Cellular tumor antigen p53, Tumor suppressor p53
Product review
Please read our product review about p53: Antibodies to p53 and p53 interacting proteins.
Product Description
Rabbit anti p53 , Presentation: Serum. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Serum |
| Host | Rabbit |
| Catalog Number | NB200-525 |
| Swiss Prot. No. | P04637 |
| Quantity | 50 µl |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Rabbit Polyclonal anti-p53 | |
| Alternate names | anti-Cys 51 Stop antibody; anti-HGNC11998 antibody; anti-p53 Cellular Tumor Antigen antibody; anti-p53 Tumor Suppressor antibody; anti- Phosphoproteinp53 antibody; anti-TP53 antibody; anti-Transformation related protein 53 antibody; anti-TRP53 antibody; anti-Tumour Protein p53 antibody |
| Background | p53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro.
p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. p53 is phosphorylated at Ser6 and Ser9 by ck1d and ck1e both in vitro and in vivo. Phosphorylation of p53 at Ser46 is important in regulating the ability of p53 to induce apoptosis. In vivo phosphorylation of p53 at Ser33 by cdk7/cyclin H and in response to UV irradiation has been observed. |
| Immunogen | Synthetic peptide: HLKSKKAcGQSTSTSRHKACKLMFKTC conjugated to KLH, corresponding to amino acids 368-389 of Human p53. Swiss Num.: P04637 |
| Format | Purification: Whole antisera Purity: Whole antisera BufferSystem: Serum |
| Applications | Western Blot 1/500 - 1/1000 |
| Specificity | Species: Cross-reacts with Human. Expected to cross-react with a wide range of other species due to sequence homology. Not yet tested in other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | General / background references:Yuan ZM et al. Role for p300 in stabilization of p53 in the response to DNA damage. J Biol Chem 274:1883-6 (1999). |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB200-525 p53'.
