NB200-111SS p14ARF antibody
see related secondary antibodiessee all 21 p14ARF products
0.025 ml / US$ 295 no delivery possible
Quick Overview
Rabbit anti p14ARF
Synonyms
anti-ARF antibody, anti-CDK4 inhibitor p16INK4 antibody, anti-CDK4I antibody, anti-CDKN2 antibody, anti-CDKN2A antibody, anti-Cell cycle negative regulator beta antibody, anti-CMM2 antibody, anti-Cyclin dependent kinase inhibitor 2A antibody, anti-Cyclin dependent kinase inhibitor p16 antibody, anti-INK4 antibody, anti-INK4a antibody, anti-MLM antibody, anti-MTS1 antibody, anti-Multiple tumor suppressor 1 antibody, anti-p14 antibody, anti-p16 antibody, anti-p16INK4 antibody, anti-TP16 antibody,
Product Description
Rabbit anti p14ARF , Presentation: Aff - Purified. Product is tested for Immunofluorescence ( IF ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunofluorescence ( IF ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | NB200-111SS |
| Quantity | 0.025 ml |
| Price | US$ 295 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Polyclonal anti-p14ARF **Sample Size** | |
| Alternate names | anti-ARF antibody, anti-CDK4 inhibitor p16INK4 antibody, anti-CDK4I antibody, anti-CDKN2 antibody, anti-CDKN2A antibody, anti-Cell cycle negative regulator beta antibody, anti-CMM2 antibody, anti-Cyclin dependent kinase inhibitor 2A antibody, anti-Cyclin dependent kinase inhibitor p16 antibody, anti-INK4 antibody, anti-INK4a antibody, anti-MLM antibody, anti-MTS1 antibody, anti-Multiple tumor suppressor 1 antibody, anti-p14 antibody, anti-p16 antibody, anti-p16INK4 antibody, anti-TP16 antibody |
| Concentration | 1 mg/ml |
| Background | The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF. (1-3) |
| Immunogen | A synthetic peptide made to a portion of human p14ARF (between residues 50-150) . |
| Format | Purification: Affinity purified Purity: Affinity purified BufferSystem: Tris-glycine, 150mM NaCl, and 0.05% sodium azide. |
| Applications | IF, WB, ECL |
| Specificity | Species: NB 200-111 reacts with human p14 ARF. Other species untested. |
| References | 1. Newcomb, E.W., et al. Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas. Human Pathology. 31(1): 115-9, 2000. 2. Taniguchi, T., et al. Expression of p16INK4a and p14ARF in hematological malignancies. Leukemia. 13(11): 1760-9, 1999. 3. Simon, M. et al. Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2A (p15) gene activation in malignant gliomas. Acta Neuropathol. 98(5): 444-52, 1999. 4. Herbert, B., et al. p16INK4a inactivation is not required to immortalize human mammary epithelial cells. Oncogene. 21:7897-7900, 2002. 5. Magro, P., et al. p14(ARF) Expression Increases Dihydrofolate Reductase Degradation and Paradoxically Results in Resistance to Folate Antagonists in Cells with Nonfunctional p53. Cancer Research. 64: 4338-4345, June 15, 2004. 1. Miller, S. J., et al. Large-Scale Molecular Comparison of Human Schwann Cells to Malignant Peripheral Nerve Sheath Tumor Cell Lines and Tissues. 66: 2584-2591 (2006) |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB200-111SS p14ARF'.
