NB110-59085 p14ARF antibody
see related secondary antibodiessee all 21 p14ARF products
0.1 ml / US$ 435 no delivery possible
Quick Overview
Rabbit anti p14ARF
Synonyms
anti-ARF antibody, anti-CDK4 inhibitor p16INK4 antibody, anti-CDK4I antibody, anti-CDKN2 antibody, anti-CDKN2A antibody, anti-Cell cycle negative regulator beta antibody, anti-CMM2 antibody, anti-Cyclin dependent kinase inhibitor 2A antibody, anti-Cyclin dependent kinase inhibitor p16 antibody, anti-INK4 antibody, anti-INK4a antibody, anti-MLM antibody, anti-MTS1 antibody, anti-Multiple tumor suppressor 1 antibody, anti-p14 antibody, anti-p16 antibody, anti-p16INK4 antibody, anti-TP16 antibody,
Product Description
Rabbit anti p14ARF , Presentation: Aff - Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | NB110-59085 |
| Quantity | 0.1 ml |
| Price | US$ 435 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Polyclonal anti-p14ARF | |
| Alternate names | anti-ARF antibody, anti-CDK4 inhibitor p16INK4 antibody, anti-CDK4I antibody, anti-CDKN2 antibody, anti-CDKN2A antibody, anti-Cell cycle negative regulator beta antibody, anti-CMM2 antibody, anti-Cyclin dependent kinase inhibitor 2A antibody, anti-Cyclin dependent kinase inhibitor p16 antibody, anti-INK4 antibody, anti-INK4a antibody, anti-MLM antibody, anti-MTS1 antibody, anti-Multiple tumor suppressor 1 antibody, anti-p14 antibody, anti-p16 antibody, anti-p16INK4 antibody, anti-TP16 antibody |
| Concentration | 2.5 mg/ml |
| Background | The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1 alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF. |
| Immunogen | A synthetic peptide made to a portion of human p14ARF (between residues 100-200). |
| Format | Purification: Affinity purified Purity: Affinity purified BufferSystem: Tris-glycine, 150mM NaCl |
| Applications | WB, ECL |
| Specificity | Species: NB 200-59085 reacts with human p14ARF. Other species have not been tested. |
| References | 1. Fatyol, K., et al. The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1 alpha (HIF-1 alpha) and Inhibits HIF-1-mediated Transcription. Journal of Biological Chemistry. 276(30): 28421-28429 (2001) 2. Kuo, M., et al. N-terminal polyubiquitination and degradation of the Arf tumor suppressor. Genes and Development. 18: 1862-1874 (2004) 3. Miller, S., et al. Large-Scale Molecular Comparison of Human Schwann Cells to Malignant Peripheral Nerve Sheath Tumor Cell Lines and Tissues. Cancer Res. 66(5): 2584-2591 (2006) |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB110-59085 p14ARF'.
