NB110-57654 ZAP70 antibody
see related secondary antibodiessee all 47 ZAP70 products
.1 ml / US$ 515 no delivery possible
Quick Overview
Rabbit anti ZAP70 YE291
Synonyms
anti-70 kDa zeta associated protein antibody, anti-Selective T cell defect antibody, anti-SRK antibody, anti-STD antibody, anti-Syk related tyrosine kinase antibody, anti-Truncated ZAP kinase antibody, anti-Tyrosine protein kinase ZAP70 antibody, anti-TZK antibody, anti-ZAP-70 antibody, anti-Zeta chain associated protein kinase 70kDa isoform 1 antibody, anti-Zeta chain associated protein kinase 70kDa isoform 2 antibody,
Product Description
Rabbit anti ZAP70 YE291. Product is tested for Flow cytometry ( F ), Frozen sections ( C ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ), Immunofluorescence ( IF )
Properties
| Applications | Flow cytometry ( F ), Frozen sections ( C ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ), Immunofluorescence ( IF ) |
| Reactivity | Human ( Hu ) |
| Host | Rabbit |
| Isotype | IgG |
| Clone | YE291 |
| Catalog Number | NB110-57654 |
| Quantity | .1 ml |
| Price | US$ 515 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Monoclonal anti-ZAP70 (YE291) | |
| Alternate names | 70 kDa zeta associated protein antibody Selective T cell defect antibody SRK antibody STD antibody Syk related tyrosine kinase antibody Truncated ZAP kinase antibody Tyrosine protein kinase ZAP70 antibody TZK antibody ZAP-70 antibody Zeta chain associated protein kinase 70kDa isoform 1 antibody Zeta chain associated protein kinase 70kDa isoform 2 antibody |
| Background | Zap-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell receptor (TCR) activation (1). TCR-mediated activation of the Src-family kinases, Lck and Fyn, results in tyrosine phosphorylation of the TCR zeta and CD3 chains. These domains serve as targets for binding of ZAP-70 via its tandem SH2 domains. This binding correlates with activation of ZAP-70, a critical event in T cell activation (2). Following TCR engagement, ZAP-70 is phosphorylated on several tyrosine residues, presumably by two mechanisms: an autophosphorylation and a trans-phosphorylation by the Src-family tyrosine kinase, Lck. Phosphorylation of Tyr319 is required for full activation and increased positive downstream regulation by ZAP-70 (3). |
| Format | BufferSystem: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Applications | FACS, IHC, IP, WB, ICC |
| Specificity | Species: Reacts in human. Does not react in mouse or rat. Not tested in other species. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB110-57654 ZAP70'.
