NB100-75389 p18 INK4c antibody
see related secondary antibodies
0.05 mg / US$ 485 no delivery possible
Quick Overview
Chicken anti p18 INK4c
Synonyms
anti-CDK6 inhibitor p18 antibody, anti-CDKN 2C antibody, anti-CDKN 6 antibody, anti-CDKN2C antibody, anti-CDKN6 antibody, anti-Cyclin dependent kinase 4 inhibitor C antibody, anti-Cyclin dependent kinase 6 inhibitor antibody, anti-Cyclin dependent kinase 6 inhibitor p18 antibody, anti-Cyclin dependent kinase inhibitor 2C antibody, anti-INK4C antibody, anti-OTTHUMP00000046546 antibody, anti-p18 antibody, anti-p18 inhibits CDK4 antibody, anti-p18 INK4c antibody, anti-p18 INK6 antibody,
Product Description
Chicken anti p18 INK4c , Presentation: Aff - Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Chicken |
| Catalog Number | NB100-75389 |
| Quantity | 0.05 mg |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Chicken Polyclonal anti-p18 INK4c | |
| Alternate names | anti-CDK6 inhibitor p18 antibody, anti-CDKN 2C antibody, anti-CDKN 6 antibody, anti-CDKN2C antibody, anti-CDKN6 antibody, anti-Cyclin dependent kinase 4 inhibitor C antibody, anti-Cyclin dependent kinase 6 inhibitor antibody, anti-Cyclin dependent kinase 6 inhibitor p18 antibody, anti-Cyclin dependent kinase inhibitor 2C antibody, anti-INK4C antibody, anti-OTTHUMP00000046546 antibody, anti-p18 antibody, anti-p18 inhibits CDK4 antibody, anti-p18 INK4c antibody, anti-p18 INK6 antibody |
| Background | p18 INK4c is a specific inhibitor of cdk4 / cdk6 (interacts strongly with CDK6 and weakly with CDK4), and is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S phase. Highest expression levels found in skeletal muscle. Also found in pancreas and heart. |
| Immunogen | The immunogen for this antibody was a sequence from 1a.a. to 168a.a. from p18 INK4c(a 168a.a. long protein) |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: Phosphate-Buffered Saline. |
| Applications | Western Blot |
| Specificity | Species: This antibody is reactive against Human, mouse, rat. |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| References | [1] Uziel,T., Zindy,F., Xie,S., Lee,Y., Forget,A., Magdaleno,S., Rehg,J.E., Calabrese,C., Solecki,D., Eberhart,C.G., Sherr,S.E.,, et al. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
[2] Matsuzaki,Y., Takaoka,Y., Hitomi,T., Nishino,H. and Sakai,T., et al. Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c) [3] Sanchez-Aguilera,A., Delgado,J., Camacho,F.I., Sanchez-Beato,M., Sanchez,L., Montalban,C., Fresno,M.F., Martin,C., Piris,M.A. and, et al. Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas [4] Komata,T., Kanzawa,T., Takeuchi,H., Germano,I.M., Schreiber,M., Kondo,Y. and Kondo,S. Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells [5] Arcellana-Panlilio,M.Y., Egeler,R.M., Ujack,E., Magliocco,A., Stuart,G.C., Robbins,S.M. and Coppes,M.J. Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors [6] , Guan K.-L., Jenkins C.W., Li Y., Nichols M.A., Wu X., O'Keefe C.L., Matera G.A., Xiong Y. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. [7] , Blais A., Labrie Y., Pouliot F., Lachance Y., Labrie C. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. [8] , Rieder M.J., Braun A.C., Montoya M.A., Chung M.-W., Nguyen C.P., Nguyen D.A., Livingston R.J., Poel C.L., Robertson P.D., Schackwitz W.S., et al. NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). [9] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [10] , Lapointe J., Lachance Y., Labrie Y., Labrie C. A p18 mutant defective in CDK6 binding in human breast cancer cells. |
11 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1300B | Chicken IgG (H&L) | ||||||
| Rabbit | Biotin | 1.5 mg / US$ 325 | |||||
| R1300F | Chicken IgG (H&L) | ||||||
| Rabbit | FITC | 1.5 mg / US$ 295 | |||||
| R1300T | Chicken IgG (H&L) | ||||||
| Rabbit | TRITC | 1.5 mg / US$ 305 | |||||
| R1300TR | Chicken IgG (H&L) | ||||||
| Rabbit | Texas Red | 1.5 mg / US$ 335 | |||||
| R1300HRP | Chicken IgG (H&L) | ||||||
| Rabbit | HRP | 1.5 mg / US$ 315 | |||||
| R1300AP | Chicken IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 355 | |||||
| R1434C2 | Chicken IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1434C3 | Chicken IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1434C35 | Chicken IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1434C5 | Chicken IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1434C55 | Chicken IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
Click here to see all secondary antibodies for 'NB100-75389 p18 INK4c'.
