NB100-309 ATM antibody
see related secondary antibodiessee all 81 ATM products
0.1 mg / US$ 515 no delivery possible
Quick Overview
Mouse anti ATM 2C1
Synonyms
Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ,
Product review
Please read our product review about ATM: Antibody Panel to ATM Kinase.
Product Description
Mouse anti ATM 2C1, Presentation: Purified. Product is tested for Frozen sections ( C ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Frozen sections ( C ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Monkey ( Mky ), Rat ( Rt ), Mouse ( Ms ) |
| Presentation | Purified |
| Host | Mouse |
| Isotype | IgG1 |
| Clone | 2C1 |
| Catalog Number | NB100-309 |
| Swiss Prot. No. | Q13315 |
| Quantity | 0.1 mg |
| Price | US$ 515 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Mouse Monoclonal anti-ATM (2C1) | |
| Alternate names | anti-AT complementation group A antibody, anti-AT complementation group C antibody, anti-AT complementation group D antibody, anti-AT complementation group E antibody, anti-AT mutated protein antibody, anti-AT1 antibody, anti-ATA antibody, anti-Ataxia telangiectasia gene mutated antibody |
| Background | Ataxia-telangiectasia (A-T) is a recessive childhood disease caused by mutations in the ATM (AT-mutated) gene. Symptoms include neurological abnormalities that cause unsteady posture, dilated blood vessels, infertility, radiation sensitivity, immune deficiencies and lymphoid malignancies. It appears that the diverse defects seen in ATM null mammals are manifestations of disparate signal transduction defects.
The ATM protein is related to a family of proteins through a c-terminal phoshatidylinositol 3-kinase (PI3-kinase) domain. Members of the PI3-kinase family of proteins are involved in cell cycle control, DNA replication, recombination and repair. ATM also shares sequence homology with portions of the yeast RAD3 gene. The main role of ATM appears to be induction of a DNA-damage control pathway in response to genotoxic insults, such as ionizing radiation or anti-tumor medications and the programmed DNA breaks of meiosis. |
| Immunogen | Fusion protein expressed in E.coli corresponding to amino acids 2577-3056. Swiss Num.: Q13315 |
| Format | Purification: protein G purified Purity: protein G purified BufferSystem: PBS [pH7.2] |
| Applications | immunohistochemistry , immunofluorescence , immunoprecipitation 1-10 ug/ml, Western Blot 1:500-1:1000 |
| Specificity | Species: NB 100-309 reacts with human, monkey, rat, and mouse protein. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Suszuki, K. et al. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. JBC 274:25571-25575 (1999).
2. Chen, G. et al. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. JBC 271:33693-33697 (1996). 3. Kozlov, S. et al. J. Biol. Chem. 278:9309-9317, 2003. 4. Perkins, E.J. et al. Genes & Dev. 16:159-164, 2002. 5. Scherthan, H. et al. Mol. Cell Bio. 20:7773,7783, 2000. 6. Li, S. et al. Nature. 406:210-215, 2000. 7. Vemuri, M.C. et al. Cell Death & Diff. 8:245-255, 2001. 8. Beamish, H. et al. J. Biol. Chem. 277:30515-30523, 2002. 9. Hu, B. et al. J. Biol. Chem. 276:17693-17698, 2001. 10. Kim, J. et al. J. Biol. Chem. 277:45149-45153, 2002. 11. Fedier, M. Oncogene. 14:938-945, 2003. Scott, S.P. et al. PNAS. 99:925-930, 2003. 12. Dork, T. et al. Cancer Res. 61:7608-7615, 2001. 13. Smilenov, L.B. et al. Cancer Res. 61:5710-5713, 2001. 14. Borghesani, P.R. et al. PNAS. 97:336-3341, 2000. 15. Wang, Y. et al. Genes & Dev. 14:927-939, 2000. 16. Araki, R. et al. Cancer Res. 59:3543-3546, 1999. 17. Weil, M.M. et al. Oncogene. 20:4409-4411, 2001. 18. Cortes, M.L. et al. Gene Therapy. 10:1321-1327, 2003. 19. Girard, P. Oncogene. 21:4191-4199, 2002. |
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-309 ATM'.
