NB100-219 ATM antibody
see related secondary antibodiessee all 81 ATM products
0.1 ml / US$ 485 no delivery possible
Quick Overview
Mouse anti ATM 3E8
Synonyms
Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ,
Product review
Please read our product review about ATM: Antibody Panel to ATM Kinase.
Product Description
Mouse anti ATM 3E8, Presentation: Purified. Product is tested for Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Monkey ( Mky ), Rat ( Rt ), Mouse ( Ms ) |
| Presentation | Purified |
| Host | Mouse |
| Isotype | IgG1 |
| Clone | 3E8 |
| Catalog Number | NB100-219 |
| Swiss Prot. No. | Q13315 |
| Quantity | 0.1 ml |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Mouse Monoclonal anti-ATM (3E8) | |
| Alternate names | anti-AT complementation group A antibody, anti-AT complementation group C antibody, anti-AT complementation group D antibody, anti-AT complementation group E antibody, anti-AT mutated protein antibody, anti-AT1 antibody, anti-ATA antibody, anti-Ataxia telangiectasia gene mutated antibody |
| Concentration | 1 mg/ml |
| Background | Ataxia-telangiectasia (A-T) is a recessive childhood disease caused by mutations in the ATM (AT-mutated) gene. Symptoms include neurological abnormalities that cause unsteady posture, dilated blood vessels, infertility, radiation sensitivity, immune deficiencies and lymphoid malignancies. It appears that the diverse defects seen in ATM null mammals are manifestations of disparate signal transduction defects.
The ATM protein is related to a family of proteins through a C-terminal phoshatidylinositol 3-kinase (PI3-kinase) domain. Members of the PI3-kinase family of proteins are involved in cell cycle control, DNA replication, recombination and repair. ATM also shares sequence homology with portions of the yeast RAD3 gene. The main role of ATM appears to be induction of a DNA-damage control pathway in response to genotoxic insults, such as ionizing radiation or anti-tumor medications and the programmed DNA breaks of meiosis. |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
Swiss Num.: Q13315 |
| Format | Purification: protein G purified Purity: protein G purified BufferSystem: PBS [pH 7.4] |
| Applications | immunoprecipitation 2-10 ug/ml, Western Blot 1-2 ug/ml |
| Specificity | Species: This antibody reacts with human, monkey, rat, and mouse proteins. It has not been tested for reactivity with any other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Andegeko, Y, et al. (2001) Nuclear Retention of ATM at Sites of DNA Double strand breaks. JBC. 276: 38224-38230.
2. Suzuki, K., et al. (1999) Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. JBC. 274: 25571-25575. 3. Chen, G. and Lee, E.Y-H.P. (1996) The product of the ATM gene is a 370-kDa nuclear phosphoprotein. JBC. 271: 33693- 33697. 4. Chen MJ, et al. (2001) ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation induced checkpoint activation. JBC. 276(19):16580-6. 5. Post S, et al. (2001) Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. PNAS. 6(98):13102-7. |
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-219 ATM'.
