NB100-2033 I Kappa B beta (IKBb) antibody
see related secondary antibodiessee all 5 I Kappa B beta products
0.1 ml / US$ 445 no delivery possible
Quick Overview
Rabbit anti I Kappa B beta (IKBb)
Product Description
Rabbit anti I Kappa B beta (IKBb) , Presentation: Serum. Product is tested for Enzyme Immunoassay ( E ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Enzyme Immunoassay ( E ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Serum |
| Host | Rabbit |
| Catalog Number | NB100-2033 |
| Quantity | 0.1 ml |
| Price | US$ 445 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Rabbit Polyclonal anti-IkB beta | |
| Alternate names | anti-IKB beta antibody, anti-I kappa B beta antibody, anti-IkappaBbeta antibody, anti-IKB B antibody, anti-IKBB antibody, anti-IkBbeta antibody, anti-NF kappa B inhibitor beta antibody, anti-NF kappa BIB antibody, anti-NFKBIB antibody, anti-Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta antibody, anti-Thyroid receptor interacting protein 9 antibody, anti-TR interacting protein 9 antibody, anti-TRIP 9 antibody, anti-TRIP9 antibody |
| Background | Three major forms of IkB-like molecules have been identified and each is characterized by multiple copies of ankyrin repeats. IkB-alpha and IkB-beta appear to be the major regulatory forms of IkB in most cells. These proteins interact with p65 or c-Rel containing forms of NFkB and block nuclear import by masking the nuclear localization sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IkB. Immunoblotting easily detects the hyper-phosphorylated forms of IkB-alpha, but not phosphorylated IkB-beta. Interestingly, IkB-alpha and IkB-beta mediate different NFkB responses. IkB-alpha appears to control more transient activation of NFkB in response to an inducer, while IkB-beta controls a persistent response. Bcl-3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IkB is confirmed by immunoblotting. |
| Immunogen | Synthetic peptide (IkB beta) conjugated to KLH - which corresponds to a region near the C-terminus of the human protein. |
| Format | Purification: Whole antisera Purity: Whole antisera BufferSystem: Preservative: 0.01% Sodium Azide |
| Applications | ELISA, immunoprecipitation, Western Blot |
| Specificity | Species: Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| References | General / background references:Baldwin AS The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-83 (1996). |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-2033 I Kappa B beta (IKBb)'.