NB100-1992 Superoxide Dismutase 2 (SOD2) (MnSOD) antibody
see related secondary antibodiessee all 31 Superoxide Dismutase 2 products
50 µg / no delivery possible
Quick Overview
Rabbit anti Superoxide Dismutase 2 (SOD2) (MnSOD)
Synonyms
SOD-2, Mn-SOD, , IPO-B, , superoxide dismutase 2, mitochondrial
Product review
Please read our product review about Superoxide Dismutase 2 (SOD2) (MnSOD): Antibody Panel to proteins of the superoxide dismutase enzyme family (SOD1, SOD2, SOD3, SOD4).
Product Description
Rabbit anti Superoxide Dismutase 2 (SOD2) (MnSOD) , Presentation: Aff - Purified. Product is tested for Enzyme Immunoassay ( E ), Frozen sections ( C ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Enzyme Immunoassay ( E ), Frozen sections ( C ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ), Xenopus ( Xen ), Bovine ( Bov ), Chicken ( Chk ), Canine ( Can ), Genua Pig ( GP ), Hamster ( Hst ), Monkey ( Mky ), Por ( Por ), Rabbit ( Rb ), Sheep ( Sh ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | NB100-1992 |
| Swiss Prot. No. | P04179 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Rabbit Polyclonal anti-MnSOD | |
| Alternate names | anti-IPO B antibody, anti-Manganese SOD antibody, anti-Manganese superoxide dismutase antibody, anti-SOD-2 antibody, anti-Superoxide dismutase [Mn] mitochondrial precursor antibody, anti-Superoxide dismutase 2 mitochondrial antibody, anti-Superoxide Dismutase 2 antibody |
| Concentration | 1.0 mg/ml |
| Background | Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria (6). Mn SOD has also been shown to be a tumor suppressor in human breast cancer (7). Overexpression of this enzyme protects neurons from NMDAand nitric oxide-induced neurotoxicity. |
| Immunogen | Full length protein (Rat). Swiss Num.: P04179 |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: 0.1M sodium phospate, pH7.0, 15-20mg/ml BSA |
| Applications | immunohistochemistry 2 ug/ml, immunoprecipitation 10 ug/ml, Western Blot 1/2000 (ECL), 0.1ug/ml (Colorimetric), EIA, |
| Specificity | Species: Cross-reacts with Human, Mouse, Rat, Xenopus laevis, Cow, Chicken, Dog, Drosophilia melanogaster, Guinea pig, Hamster, Monkey, Pig, Rabbit and Sheep. Not yet tested in other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Kurobe, N., Inagaki, T., Kato, K. (1990) Clinica Chimica Acta 192: 171-180.
2. Kurobe, N., Suzuki, F., Okajima, K., Kato, K. (1990) Clinica Chimica Acta 187: 11-20. 3. Wong, G.H., Elwell, J.H., Oberley, L.W., Goeddel, D.V. (1989) Cell 58: 923-931. 4. Manna, S.K., Zhang, H.J., Yan, T., Oberley, L.W., Aggarwal, B.B. (1998) J. Biol. Chem. 273: 13245-13254. 5. Gonzalez-Zulueta, M., Ensz, L.M., Mukhina, G., Lebovitz, R.M., Zwacka, R.M., Engelhardt, J.F., Oberley, L.W., Dawson, V.L., Dawson, T.M. (1998) J. Neurosci 18: 2040-2055. 6. Li, Y., Huang, T.T., Carlson, E.J., Melov, S., Ursell, P.C., Olson, J.L., Noble, L.J., Yoshimura, M.P., Berger, C., Chan, P.H. (1995) Nat. Genet. 11: 376-381. 7. Ojika T., Imaizumi,M., Watanabe, H., Sakakibara, M., Abe, T., Kato, K. (1991) Acta Histochem Cytochem 24(5): 489-495. 8. Kurobe, N., Kato, K. (1991) Biomed. Rsch. 12: 97-103. 9. Xiao-Hong Liu, et al., (1993) Brain Res. 625: 29-37. 10. Bidmon, H-J., Kato, K., Schleicher, A., Witte, O.W., Zilles, K. (1998) Stroke 29: 203-211. 11. Hadjur, S., Ung, K., Wadsworth, L., Dimmick, J., Rajcan-Separovic, E., Scott, R.W., Buchwald, M., Jirik, F.R. (2001) Blood 98(4): 1003-1011. 12. Katsuki, H., Tomita, M., Takenaka, C., Shirakawa, H., Shimazu, S., Ibi, M., Kume, T., Kaneko, S., Akaike, A. (2001) J Neurochem 76(5): 1336-1345. 13. Guo, W., Adachi, T., Matsui, R., Xu, S., Jiang, B., Zou, M.H., Kirber, M., Lieberthal, W., Cohen, R.A. (2003) Am J Physiol 285(4): H1396-H1403. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-1992 Superoxide Dismutase 2 (SOD2) (MnSOD)'.