AP00414PU-N TR alpha / THRA / NR1A1 (ligand binding dom.) antibody
see related secondary antibodiessee all 9 TR alpha / THRA / NR1A1 products
50 µg / US$ 515
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti TR alpha / THRA / NR1A1 (ligand binding dom.)
Synonyms
Thyroid Hormone Receptor alpha, ERBA1, C-erbA-alpha, c-erbA-1, EAR-7, EAR7, THRA1, THRA2, , Nuclear receptor subfamily 1 group A member 1, erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian
Product review
Please read our product review about TR alpha / THRA / NR1A1 (ligand binding dom.): Antibody Panel to Thyroid Hormone Receptor (TR).
Product Description
Rabbit anti TR alpha / THRA / NR1A1 (ligand binding dom.) , Presentation: Aff - Purified. Product is tested for Paraffin Sections ( P )
Properties
| Applications | Paraffin Sections ( P ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | AP00414PU-N |
| Swiss Prot. No. | P10827 |
| Quantity | 50 µg |
| Price | US$ 515 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  AP00414PU-N.pdf |
Datasheet Extract
| Alternate names | THRA, avian erythroblastic leukemia viral oncogene homolog, c-erba-1, C-erba-alpha, c-erbaalpha, ear-7, erba-alpha, erba1, hTR alpha 1, hTR alpha 2, nr1a1, T3R, thra, thyroid hormone receptor, thyroid hormone receptor alpha1, Thyroid hormone receptor alpha, Tr alpha, Tralpha, Tralpha1, Tralpha2, triiodothyronine receptor p43 |
| Concentration | 1 mg/ml |
| Background | Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410 aa) (Nakai et al. 1988), TR alpha2 (490 aa) (Nakai et al. 1988), TR deltaalpha1 (~154 aa), and TR deltaalpha2 (~237 aa); however, only TR alpha1 is able to bind the ligand (Lazar et al. 1988). TR alpha1 and TR alpha2 are products of alternative splicing of the primary TR alpha mRNA, whereas TR deltaalpha1 and TR deltaalpha2 arise from transcription of an internal promoter in intron 7 of the TR alpha gene. A truncated form of TR alpha, called p43 for 43-kDa, has been shown to regulate mitochondrial transcription Casas et al. 2003. Mice lacking all forms of TR alpha have been shown to be viable, but show reduced linear growth, delayed bone maturation, increased hypothermia, reduced thickness of the intestinal mucosa, lowered heart rates, and lowered serum T4. TR alpha has been linked to chronic fatigue Englebienne et al. 2003. |
| Immunogen | Synthetic peptide, ligand-binding domain of human THRA - KLH conjugated Genename: THRA Swiss Num.: P10827 |
| Format | State: Liquid Purification: Peptide immunogen affinity column. BufferSystem: Phosphate buffered saline, PH 7.7 containing 0.01% sodium azide. |
| Applications | Immunohistochemistry: 10 µg/ml. |
| Specificity | This antibody detects Thyroid Hormone Receptor Alpha (TR Alpha/NR1A1).
Mouse Identity: 95 % Mouse Similarity: 100 % Species: Human, Mouse. |
| Storage | Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. |
| Pictures | Immunohistochemistry Image: Surface Epithelium, stained with AP00414PU-N |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
